Clusters of firms in space and time

The use of the K-functions (Ripley, 1977) has become recently popular in the analysis of the spatial pattern of firms. It was first introduced in the economic literature by Arbia and Espa (1996) and then popularized by Marcon and Puech (2003), Quah and Simpson (2003), Duranton and Overman (2005) and Arbia et al. (2008). In particular in Arbia et al. (2008) we used Ripley’s K-functions as instruments to study the inter-sectoral co-agglomeration pattern of firms in a single moment of time. All this researches have followed a static approach, disregarding the time dimension. Temporal dynamics, on the other hand, play a crucial role in understanding the economic and social phenomena, particularly when referring to the analysis of the individual choices leading to the observed clusters of economic activities. With respect to the contributions previously appeared in the literature, this paper uncovers the process of firm demography by studying the dynamics of localization through space-time K-functions. The empirical part of the paper will focus on the study of the long run localization of firms in the area of Rome (Italy), by concentrating on the ICT sector data collected by the Italian Industrial Union in the period 1920- 2005.Agglomeration, Non-parametric measures; Space-time K-functions, Spatial clusters, Spatial econometrics.

Commissioning of the DAΦNE beam test facility

Abstract The DAΦNE Beam Test Facility (BTF) is a beam transfer line optimized for the production of electron or positron bunches, in a wide range of multiplicities and down to single-electron mode, in the energy range between 50 and 800 MeV . The typical pulse duration is 10 ns and the maximum repetition rate is 50 Hz . The facility design has been optimized for detector calibration purposes. The BTF has been successfully commissioned in February 2002 and started operation in the same year in November. The schemes of operation, the commissioning results, as well as the first users' experience are reported here

A case report of a rare intramuscular granular cell tumor

Background: Granular cell tumors (GCTs) were firstly described by Weber in 1854 and 70 years later by Abrikossoff and classified as benign tumors. Originally considered muscle tumors, they have been identified as neural lesions, due to their close association with nerve and to their immunohystochemical characteristics. GCTs are uncommon tumors and they may arise in any part of the body; they have been mainly observed in tongue, chest wall and upper extremities; less frequent sites are larynx, gastrointestinal tract, breast, pituitary stalk and the female anogenital region. Here we report a case of GCT showing an uncommon localization such as the upper third of the right rectus muscle of the abdominal wall. Case presentation: A 45 year-old woman of Caucasian origin presented to the surgeon with a 6-month history of light pain in the upper third of the abdominal wall. Radiological exams (Ultrasonography, Computed Tomography and Contrast magnetic resonance imaging) showed a localized in the right rectus abdominis muscle. After excision, histological and immunohystochemical analysis, with the support of electron microscopy, allowed making diagnosis of granular cell tumor. Discussion: After fist description by Abrikosoff in 1926 of GCT like mesenchymal tumor of unknown origin, in recent years immunohystochemical techniques definitely demonstrated the histogenetic derivation of GCT from Schwann cells. Granular cell tumors are rare, small, slow-growing, solitary and painless subcutaneous nodules which behave in a benign fashion, but can have a tendency to recur; in rare cases they can metastasize, when they became malignant; there are some clinical and histological criteria to suspect the malignance of this tumor. Conclusion: It is important that clinicians, radiologists and pathologists are aware of the clinical presentation and histopathology of GCT for appropriate management, counselling and follow-up. In our case we had a complete radiological, morphological and immunohystochemical characterization of the lesion and a definitive diagnosis of benignity confirmed by electron microscopy

Interference effects in the H(→ γγ) + 2 jets channel at the LHC

We compute the interference between the resonant process pp → H(→ γγ) + 2 jets and the corresponding continuum background at leading order in QCD. For the Higgs signal, we include gluon fusion (GF) and vector boson fusion (VBF) production channels, while for the background we consider all tree-level contributions, including pure EW effects (O(α 4 QED)) and QCD contributions (O(α 2 QEDα 2 s )), plus the loopinduced gluon-initiated process. After convolution with the experimental mass resolution, the main effect of the interference is to shift the position of the mass peak, as in the inclusive GF case studied previously. The apparent mass shift is small in magnitude but strongly dependent on the Higgs width, potentially allowing for a measurement of, or bound on, the width itself. In the H(→ γγ) + 2 jets channel, the VBF and GF contributions generate shifts of opposite signs which largely cancel, depending on the sets of cuts used, to as little as 5 MeV (toward a lower Higgs mass). The small magnitude of the shift makes this channel a good reference mass for measuring the inclusive mass shift of around 60 MeV in the Standard Model.Fil: Coradeschi, F.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Università degli Studi di Firenze; ItaliaFil: de Florian, Daniel Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Dixon, L. J.. University of Stanford; Estados Unidos. Walter Burke Institute for Theoretical Physics; Estados UnidosFil: Fidanza Romani, Nerina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Höche, S.. University of Stanford; Estados UnidosFil: Ita, H.. Albert Ludwigs Universität Freiburg; AlemaniaFil: Li, Y.. University of Stanford; Estados UnidosFil: Mazzitelli, Javier Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentin

New Challenges for Sustainable Organizations in Light of Agenda 2030 for Sustainability

Sustainability is one of humanity’s most daunting issues at present. Increasing popula- tion, escalation of anthropogenic activities, industrialization, modern agricultural practices that pollute water, air, and soil around the world, and ever-increasing greenhouse gas emissions mean that sustainability is now in doubt [1]. In response to these critical concerns, the world has come up with several initiatives including Agenda 2030. Agenda 2030 is a commitment to eradicate poverty and achieve sustainable development worldwide, ensuring that no one is left behind by 2030. Its adoption was a landmark achievement, providing a shared vision towards sustainable development for all. Its 17 Sustainable Development Goals (SDGs) and 169 targets aim to end the plethora of development problems and deliver a better univers

Off-Label Use of Dalbavancin for Sequential Treatment of Spondylodiscitis by Methicillin-Resistant Staphylococcus aureus: A Retrospective Single-Centre Experience

Background: Our aim was to describe the clinical outcome and safety of the sequential treatment with off-label dalbavancin in patients with spondylodiscitis that is caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: We retrospectively included all patients >18 years of age with spondylodiscitis that is caused by MRSA that was treated with dalbavancin from January 2018-January 2021, recording the instances of clinical cure/failure, adverse events, and the need to be re-hospitalized after the initiation of dalbavancin. In 2/15 patients, we performed therapeutic drug monitoring (TDM) for dalbavancin. Results: We included 15 patients, 53.3% of them were females, with a median age of 67.9 years (57.4-78.5); 100% patients reported back pain, while a fever was present only in 2/15 cases. The spondylodiscitis was localized in 86.6% cases at the lumbar level. A median of a 2-week in-hospital intravenous vancomycin was followed by dalbavancin with a median duration of 12 weeks (12-16). All patients reported a clinical cure, except for a woman who is still on a suppressive treatment. No patient needed to be re-hospitalized, access to emergency department, or experienced adverse events. The TDM for dalbavancin showed that more than 90% of the determinations were above the pharmacodynamic target against staphylococci. Conclusions: The results from our unique, even if it was small, cohort demonstrated that dalbavancin can be a safe/effective option as a sequential treatment in patients with serious infections requiring prolonged antibiotic therapy, such as spondylodiscitis

Predictors for New-Onset Complete Heart Block After Transcatheter Aortic Valve Implantation

ObjectivesThe aim of this study was to identify risk factors for new-onset atrioventricular (AV) block requiring pacemaker (PM) implantation after transcatheter aortic valve implantation (TAVI).BackgroundHigh-grade AV block and consecutive PM implantation are frequent complications following TAVI.MethodsFor logistic regression analysis, we included 159 patients (mean age: 81 ± 6 years, EuroSCORE: 22 ± 13%) who underwent TAVI (n = 116 transfemoral, n = 4 via subclavian artery, n = 37 transapical, n = 2 transaortic) between June 2007 and January 2009 and who had no previously implanted PM.ResultsThirty-five patients (22%) developed new-onset post-operative AV block with the need of PM implantation. Logistic regression revealed a 2-fold increased risk for new-onset AV block in patients in whom a large valve is implanted in a small annulus (32% pacemaker implantations, odds ratio [OR]: 2.378, p = NS), a 4-fold increased risk with the implantation of the CoreValve (Medtronic, Minneapolis, Minnesota) versus the Edwards Sapien valve (Edwards Lifesciences, Irvine, California) (27% pacemaker implantations, OR: 3.781, p = NS), and a 5-fold increased risk for patients who exhibit an AV block episode instantly during the implantation procedure (49% pacemaker implantations, OR: 4.819, p = 0.001). Pre-existing ECG alterations were not identified as risk factors for AV block after transcatheter aortic valve implantation.ConclusionsWe assume that conduction tissue impairment is provoked by mechanical compression with large prostheses in smaller annuli or in the larger area of the CoreValve covering the outflow tract and may appear instantly during the implantation procedure. Continuous post-operative electrocardiogram monitoring should be performed for at least 3 days in all patients after TAVI procedures and until discharge in patients with increased risk for this complication

Pollinator and predator insects biodiversity in vineyards agroecosystems of Mendoza, Argentina : considerations for habitat management

El presente estudio expone los primeros resultados obtenidos acerca de la influencia del manejo de hábitat con vegetación nativa sobre los servicios ecosistémicos ofrecidos por insectos polinizadores y controladores de plagas, en viñedos de la provincia de Mendoza, Argentina. El trabajo se realizó en tres viñedos situados en Gualtallary, departamento de Tupungato, los cuales presentan corredores biológicos con diferentes proporciones de vegetación nativa y un manejo del espacio interfilar con coberturas. Con el objetivo de determinar los grupos relevantes de insectos benéficos en corredores y en viñedos, se realizaron muestreos con red entomológica. Se identificaron las especies colectadas y se estimó la riqueza, diversidad y abundancia de insectos polinizadores (Apidae, Andrenidae, Colletidae, Halictidae, Megachilidae y Syrphidae), así como de ciertos grupos de insectos depredadores (Coccinellidae, Nabidae, Reduviidae, Geocoridae, Anthocoridae, Chrysopidae, Hemerobiidae, Crabronidae y Sphecidae), que se encontraron en esos ambientes. Los resultados sugieren que el manejo de hábitat con provisión intencional de coberturas de vegetación nativa, y en particular de especies con flores atractivas para insectos, es potencialmente eficiente para favorecer la biodiversidad de los grupos funcionales estudiados y, por lo tanto, el mantenimiento de los servicios ecosistémicos ofrecidos por estos.This study exposes first results about the influence of habitat management with native vegetation on the ecosystem services offered by pollinators and pest controller insects, in vineyards of Mendoza, Argentina. The work was carried out in three vineyards located in Gualtallary, department of Tupungato, which present biological corridors and inter-row coverings with different proportions of native vegetation. In order to determine relevant groups of beneficial insects present, samples with entomological net were taken in corridors and vineyards. The specimens captured were identified and richness, diversity and abundance of pollinating insects (Apidae, Andrenidae, Colletidae, Halictidae, Megachilidae and Syrphidae) were estimated, as well as of certain groups of predatory insects (Coccinellidae, Nabidae, Reduviidae, Geocoridae, Anthocoridae, Chrysopidae, Hemerobiidae, Crabronidae and Sphecidae), which were found in those environments. Results suggest that habitat management with intentional provision of native vegetation covers, and particularly with attracting flowering forbs, is potentially efficient to increase biodiversity of the functional groups studied and, therefore, maintain the ecosystem services offered by them.Fil: Mazzitelli, Guillermo Pablo . Instituto Argentino de Investigaciones de las Zonas Áridas Fil: Mazzitelli, María Emilia. Instituto Nacional de Tecnología Agropecuaria (Argentina)Fil: Fruitos, Andrea. Instituto Nacional de Tecnología Agropecuaria (Argentina)Fil: González, Marcela. Instituto Nacional de Tecnología Agropecuaria (Argentina). Estación Experimental Agropecuaria Mendoza.Fil: Marcucci, Bruno. Instituto Nacional de Tecnología Agropecuaria (Argentina). Estación Experimental Agropecuaria Mendoza.Fil: Giusti, Romanela. La Consulta (San Carlos, Argentina). Estación Experimental Agropecuaria INTA La Consulta.Fil: Alemanno, Valeria. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Del Barrio, Lucía. Instituto Nacional de Tecnología Agropecuaria (Argentina). Estación Experimental Agropecuaria Mendoza.Fil: Portela, José. La Consulta (San Carlos, Argentina). Estación Experimental Agropecuaria INTA La Consulta.Fil: Debandi, Guillermo. Instituto Nacional de Tecnología Agropecuaria (Argentina

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells

During inflammation, recruited monocytes can differentiate either into macrophages or dendritic cells (DCs); however, little is known about the environmental factors that determine this cell fate decision. Low extracellular pH is a hallmark of a variety of inflammatory processes and solid tumors. Here, we report that low pH dramatically promotes the differentiation of monocytes into DCs (monocyte-derived DCs [mo-DCs]). This process is associated with a reduction in glucose consumption and lactate production, the upregulation of mitochondrial respiratory chain genes, and the inhibition of mTORC1 activity. Interestingly, we also find that both serum starvation and pharmacological inhibition of mTORC1 markedly promote the differentiation of mo-DCs. Our study contributes to better understanding the mechanisms that govern the differentiation of monocytes into DCs and reveals the role of both extracellular pH and mTORC1 as master regulators of monocyte cell fate.Fil: Erra Díaz, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Ochoa, Andrea Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Merlotti Ippólito, Antonela. PSL Research University; Francia. Inserm; FranciaFil: Dantas, Ezequiel Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Mazzitelli, Ignacio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Gonzalez Polo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Sabatte, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Amigorena, Sebastián. Psl Research University; Francia. Inserm; FranciaFil: Segura, Elodie. Psl Research University; Francia. Inserm; FranciaFil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling

Astrocytes play a crucial role in neuroinflammation as part of the glia limitans, which regulates infiltration of the brain parenchyma by leukocytes. The signaling pathways and molecular events, which result from the interaction of activated T cells with astrocytes are poorly defined. Here we show that astrocytes promote the expression and enzymatic activity of CD39 and CD73 ectonucleotidases in recently activated CD4 cells by a contact dependent mechanism that is independent of T cell receptor interaction with class II major histocompatibility complex (MHC). Transforming growth factor-β (TGF-β) is robustly upregulated and sufficient to promote ectonucleotidases expression. T cell adhesion to astrocyte results in differentiation to an immunosuppressive phenotype defined by expression of the transcription factor Rorγt, which characterizes the CD4 T helper 17 subset. CD39 activity in T cells in turn inhibits spontaneous calcium oscillations in astrocytes that correlated with enhanced and reduced transcription of CCL2 chemokine and Sonic hedgehog (Shh), respectively. We hypothesize this TCR-independent interaction promote an immunosuppressive program in T cells to control possible brain injury by deregulated T cell activation during neuroinflammation. On the other hand, the increased secretion of CCL2 with concomitant reduction of Shh might promote leukocytes extravasation into the brain parenchyma